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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
SAMHD1
All Species:
30.61
Human Site:
T387
Identified Species:
56.11
UniProt:
Q9Y3Z3
Number Species:
12
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9Y3Z3
NP_056289.2
626
72201
T387
N
I
I
D
T
M
I
T
D
A
F
L
K
A
D
Chimpanzee
Pan troglodytes
XP_514624
382
43769
F157
L
G
G
G
Y
Y
V
F
P
G
A
S
H
N
R
Rhesus Macaque
Macaca mulatta
XP_001097562
728
83194
T489
N
I
I
D
T
M
I
T
D
A
F
L
K
A
D
Dog
Lupus familis
XP_542986
665
76981
T425
N
I
I
D
T
M
I
T
D
A
F
L
K
A
D
Cat
Felis silvestris
Mouse
Mus musculus
Q60710
627
72632
T399
N
L
I
D
I
M
I
T
D
A
F
L
K
A
D
Rat
Rattus norvegicus
XP_230789
677
77635
T449
N
L
I
D
I
M
I
T
E
A
F
L
K
A
D
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
Q5ZJL9
614
70202
T378
N
I
I
E
I
M
I
T
E
A
F
Q
K
A
D
Frog
Xenopus laevis
Q6INN8
632
72730
T392
N
I
I
E
T
M
I
T
D
A
F
V
K
A
D
Zebra Danio
Brachydanio rerio
Q502K2
622
71649
T367
N
I
I
E
T
M
I
T
E
A
F
L
K
A
D
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q09374
587
66474
V338
R
F
M
E
T
L
M
V
D
A
L
I
N
A
G
Sea Urchin
Strong. purpuratus
XP_784786
594
68895
V364
K
I
I
E
K
M
I
V
E
A
L
F
K
A
N
Poplar Tree
Populus trichocarpa
XP_002312899
477
54770
E252
E
I
C
Y
R
A
K
E
Y
L
T
V
H
K
L
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
NP_568580
473
54655
K248
N
E
I
C
F
R
A
K
E
Y
L
S
V
H
K
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
58.9
79.5
73.5
N.A.
73.3
65.8
N.A.
N.A.
60
61.8
60.8
N.A.
N.A.
N.A.
22.5
46.8
Protein Similarity:
100
60.2
82.4
83.6
N.A.
83.2
76.2
N.A.
N.A.
74.9
75.3
74.1
N.A.
N.A.
N.A.
40.8
64.2
P-Site Identity:
100
0
100
100
N.A.
86.6
80
N.A.
N.A.
73.3
86.6
86.6
N.A.
N.A.
N.A.
26.6
46.6
P-Site Similarity:
100
6.6
100
100
N.A.
93.3
93.3
N.A.
N.A.
86.6
100
100
N.A.
N.A.
N.A.
60
66.6
Percent
Protein Identity:
28.2
N.A.
N.A.
30.5
N.A.
N.A.
Protein Similarity:
45
N.A.
N.A.
47.2
N.A.
N.A.
P-Site Identity:
6.6
N.A.
N.A.
13.3
N.A.
N.A.
P-Site Similarity:
13.3
N.A.
N.A.
20
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
8
8
0
0
77
8
0
0
77
0
% A
% Cys:
0
0
8
8
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
39
0
0
0
0
47
0
0
0
0
0
62
% D
% Glu:
8
8
0
39
0
0
0
8
39
0
0
0
0
0
0
% E
% Phe:
0
8
0
0
8
0
0
8
0
0
62
8
0
0
0
% F
% Gly:
0
8
8
8
0
0
0
0
0
8
0
0
0
0
8
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
16
8
0
% H
% Ile:
0
62
77
0
24
0
70
0
0
0
0
8
0
0
0
% I
% Lys:
8
0
0
0
8
0
8
8
0
0
0
0
70
8
8
% K
% Leu:
8
16
0
0
0
8
0
0
0
8
24
47
0
0
8
% L
% Met:
0
0
8
0
0
70
8
0
0
0
0
0
0
0
0
% M
% Asn:
70
0
0
0
0
0
0
0
0
0
0
0
8
8
8
% N
% Pro:
0
0
0
0
0
0
0
0
8
0
0
0
0
0
0
% P
% Gln:
0
0
0
0
0
0
0
0
0
0
0
8
0
0
0
% Q
% Arg:
8
0
0
0
8
8
0
0
0
0
0
0
0
0
8
% R
% Ser:
0
0
0
0
0
0
0
0
0
0
0
16
0
0
0
% S
% Thr:
0
0
0
0
47
0
0
62
0
0
8
0
0
0
0
% T
% Val:
0
0
0
0
0
0
8
16
0
0
0
16
8
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
8
8
8
0
0
8
8
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _